Observe Closely (3)pentobarbital will lower the extent or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Sturdy or average CYP3A4 inducers may possibly raise fee of diazepam elimination; therefore, efficacy of diazepam can be lowered.pentobarbital will reduce the extent or effect